Something

<VirtualHost *>
  ServerName myfancywebsite.com
  DocumentRoot /var/www/attendance

  RewriteEngine On
  RewriteCond %{REQUEST_URI} !^/icons
  RewriteCond %{REQUEST_URI} !^/favicon.ico$
  RewriteCond %{REQUEST_URI} !^(.*)+attendance.py/
  #RewriteRule ^/(.*)$ /var/www/attendance/attendance.py/$1 [PT]
  RewriteRule ^/(.*)$ /attendance.py/$1 [PT]

</VirtualHost>

WSGIDaemonProcess attendance home=/var/www/attendance
<Directory /var/www/attendance>
  WSGIProcessGroup attendance
  WSGIPassAuthorization On
  <Files attendance.py>
    SetHandler wsgi-script
    Options ExecCGI
  </Files>
</Directory>