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Like the HA strain, CA-MRSA carry the mecA gene which codes for methicillin resistance. The HA-MRSA strain is often SCCmec type II while the CA-MRSA strain is type IV. Unlike the HA strain, CA-MRSA produces the PVL toxin.  PVL is a two component pore forming toxin complex encoded by two co-transcribed genes (lukS-PV and lukF-PV) that cause tissue necrosis and leukocyte destruction (Finck-Barbancon et al., 1993; Supersac et al., 1993; Prevost et al., 1995). Recent studies have shown that PVL is a key virulence factor in pulmonary infections and as demostrated in a murine model it was sufficient enough to cause necrotizing pneumonia (ref, Labandeira-Rey).