Something

#!/usr/bin/perl

print "9 + 16 = ", add(9, 16), "\n";
print "9 - 16 = ", subtract(9, 16), "\n";

use Inline Python => <<'END_OF_PYTHON_CODE';
def add(x,y): 
   return x + y

def subtract(x,y):
   return x - y

END_OF_PYTHON_CODE